ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of the rhizome of Ervatamia hainanensis.</p><p><b>METHOD</b>The solvent extraction and silica column chromatography were used to separate the chemical constituents, and their structures were identified by physico chemical properties and spectra analysis.</p><p><b>RESULT</b>Twelve compounds were isolated and their structures were identified as voacangine (1), ibogaine (2), ibogamine (3), coronaridine (4), 19-heyneanine (5), 19-epi-heyneanine (6), 3-hydroxyl coronaridine (7), coronaridine hydroxyindolenine (8), 3-(2-oxopropyl) coronaridine (9), vobasine (10), alpha-amyrin (11), alpha-amyrin acetate (12).</p><p><b>CONCLUSION</b>Compounds 1, 2, 6, 11 and 12 were first found from this plant.</p>
Subject(s)
Apocynaceae , Chemistry , Chromatography, Gel , Ibogaine , Chemistry , Oleanolic Acid , Chemistry , Plants, Medicinal , Chemistry , Rhizome , ChemistryABSTRACT
<p><b>AIM</b>To investigate the chemical constituents of water-soluble part of stem of Nauclea officinalis.</p><p><b>METHODS</b>The compounds were isolated and purified by resins, silica gel, and Sephadex LH20 column chromatography repeatedly, and their structures were identified by spectral analysis.</p><p><b>RESULTS</b>Seven compounds were isolated and identified as: naucleamide A-10-O-beta-D-glucopyranoside (I), 5-beta-carboxystrictosidin (II), sweroside (III), loganin (IV), 3,4-dimethoxyphenyl-beta-D-glucopyranoside (V), 3, 4, 5-trimethoxyphenyl-beta-D-glucopyranoside (VI), 2-phenethylrutinoside (VII).</p><p><b>CONCLUSION</b>Compound I is a new indole alkaloid glucoside, compounds I-VII were isolated from this plant for the first time.</p>
Subject(s)
Carbolines , Chemistry , Glucosides , Chemistry , Glycosides , Chemistry , Indole Alkaloids , Chemistry , Iridoid Glucosides , Iridoids , Chemistry , Molecular Conformation , Molecular Structure , Plant Stems , Chemistry , Plants, Medicinal , Chemistry , Rubiaceae , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of the bulbs of Bolbostemma panicultum.</p><p><b>METHOD</b>The compounds were isolated by column chromatography on silica gel, C18, Sephadex LH-20 separately and their structures were elucidated by chemical and spectroscopic technologies.</p><p><b>RESULT</b>Eight compounds were isolated and identified as maltol(I), emodin(II), cucurbitacin B(III), cucurbitacin E(IV), stigmasta-7, 22, 25-triene-3-ol(V), stigmasta-7, 22, 25-triene-3-nonadecanoic acid ester(VI), stigmasta-7, 22, 25-triene-3-O-beta-D-glucopyranoside(VII), stigmasta-7, 22, 25-triene-3-O-beta-D-(6'-palmitoyl) glucopyranoside(VIII).</p><p><b>CONCLUSION</b>I-VIII were obtained from this plant for the first time; VI and VIII are new compounds.</p>
Subject(s)
Cucurbitaceae , Chemistry , Emodin , Chemistry , Molecular Structure , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Saponins , Chemistry , Stigmasterol , Chemistry , Triterpenes , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Ervatamia hainanensis.</p><p><b>METHOD</b>The compounds were separated and purified by column chromatography with silica gel, and identified by IR, MS, NMR and 2D-NMR.</p><p><b>RESULT</b>Five compounds were identified as I (isolariciresinol 9-O-beta-D-glucopyranoside), II (cycloartenol), III (beta-amyrin acetate), IV (beta-sitosterol), V (daucosterol), respectively.</p><p><b>CONCLUSION</b>All the compounds were isolated from this plant for the first time.</p>
Subject(s)
Apocynaceae , Chemistry , Glucosides , Chemistry , Oleanolic Acid , Chemistry , Phytosterols , Chemistry , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Sitosterols , Chemistry , TriterpenesABSTRACT
<p><b>OBJECTIVE</b>To explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera.</p><p><b>METHOD</b>The rats were randomized into four groups: control group (20% PVP-water), T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transaminase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope.</p><p><b>RESULT</b>T001 and F002 showed significant liver toxicity.</p><p><b>CONCLUSION</b>The chloroform fraction was the liver-toxic fraction of D. bulbifera.</p>
Subject(s)
Animals , Female , Male , Rats , Alanine Transaminase , Blood , Bilirubin , Blood , Chemical and Drug Induced Liver Injury , Blood , Pathology , Dioscorea , Chemistry , Drugs, Chinese Herbal , Toxicity , Liver , Pathology , Plants, Medicinal , Chemistry , Random Allocation , Rats, Sprague-DawleyABSTRACT
Objective:To study the effect of total saponins on cerebral blood flow and vascular resistance in anesthetized dogs.Methods:Thirty hybrid dogs in either sex,with a body weight of(11?1.5)kg,were evenly randomized into 5 groups: negative control group(saline 5 ml/kg,ig),positive control(nimodipine 300?g/kg,iv),and 3 groups treated with total saponins (low-dose group[10 mg/kg,ig],middle-dose group[30 mg/kg,ig],and high-dose group[60 mg/kg,ig]).The dogs were anes- thetized with intravenous pentobarbital sodium(30 mg/kg).The right common carotid artery was exposed to measure the cere- bral blood flow,cerebral vascular resistance,blood pressure and heart rate using the MFV-3200 electromagnetic flow meter and MPA-3000 bioelectricity signal-amplifier.Results:Compared with negative control,cerebral blood flow was significantly in- creased in animals treated with asparagus root saponins(30 and 60 mg/kg,ig)during 5 and 120 min after drug administration (P